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Fat loss comparison

AOD-9604 vs Cagrilintide

An educational, source-based comparison of AOD-9604 and Cagrilintide — how each peptide works, what it's researched for, and what to know before going deeper.

Metabolic · Lipolysis
AOD-9604

Modified GH fragment researched for adipose tissue effects.

Mechanism

A modified 16-amino-acid fragment (177–191) of human growth hormone, engineered to retain the lipolytic activity of GH without its growth or insulin-resistance effects. Research suggests it stimulates lipolysis and inhibits lipogenesis.

Research areas
  • Obesity (clinical trials did not meet endpoints)
  • Osteoarthritis / cartilage repair (current research direction)
  • Localized adipose research
Considerations
  • Not FDA-approved as a therapeutic.
  • Has GRAS status in some food contexts (Australia), not equivalent to drug approval.
Full AOD-9604 profile →
Metabolic · Amylin
Cagrilintide

Long-acting amylin analog studied alongside GLP-1 agonists.

Mechanism

A long-acting analog of amylin, a pancreatic hormone co-secreted with insulin. It slows gastric emptying, increases satiety, and suppresses glucagon — complementary to GLP-1 mechanisms.

Research areas
  • Weight management as monotherapy and combined with semaglutide (CagriSema)
  • Glycemic control in type 2 diabetes
Considerations
  • Investigational; not yet FDA-approved as monotherapy.
  • GI side effects similar to GLP-1 agonists.
Full Cagrilintide profile →

AOD-9604 vs Cagrilintide — Key differences

  • Class: AOD-9604 is classified as Metabolic · Lipolysis, while Cagrilintide is Metabolic · Amylin.
  • Primary research focus: AOD-9604obesity (clinical trials did not meet endpoints); Cagrilintideweight management as monotherapy and combined with semaglutide (cagrisema).
  • Tag: Fat loss vs Weight loss.

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