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Fat loss comparison

5-Amino-1MQ vs AOD-9604

An educational, source-based comparison of 5-Amino-1MQ and AOD-9604 — how each peptide works, what it's researched for, and what to know before going deeper.

Metabolic · Small Molecule
5-Amino-1MQ

Small-molecule NNMT inhibitor researched for fat metabolism.

Mechanism

Not a peptide but commonly grouped in peptide research. A selective inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme overexpressed in obese adipose tissue. Inhibition increases SAM and NAD+ availability, increasing adipocyte energy expenditure in animal models.

Research areas
  • Diet-induced obesity (rodent)
  • White adipose tissue energy expenditure
  • Age-related muscle function
Considerations
  • Investigational; no human clinical trials yet.
  • Not FDA-approved.
Full 5-Amino-1MQ profile →
Metabolic · Lipolysis
AOD-9604

Modified GH fragment researched for adipose tissue effects.

Mechanism

A modified 16-amino-acid fragment (177–191) of human growth hormone, engineered to retain the lipolytic activity of GH without its growth or insulin-resistance effects. Research suggests it stimulates lipolysis and inhibits lipogenesis.

Research areas
  • Obesity (clinical trials did not meet endpoints)
  • Osteoarthritis / cartilage repair (current research direction)
  • Localized adipose research
Considerations
  • Not FDA-approved as a therapeutic.
  • Has GRAS status in some food contexts (Australia), not equivalent to drug approval.
Full AOD-9604 profile →

5-Amino-1MQ vs AOD-9604 — Key differences

  • Class: 5-Amino-1MQ is classified as Metabolic · Small Molecule, while AOD-9604 is Metabolic · Lipolysis.
  • Primary research focus: 5-Amino-1MQdiet-induced obesity (rodent); AOD-9604obesity (clinical trials did not meet endpoints).
  • Tag: Metabolic vs Fat loss.

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