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Fat loss comparison

AOD-9604 vs Survodutide

An educational, source-based comparison of AOD-9604 and Survodutide — how each peptide works, what it's researched for, and what to know before going deeper.

Metabolic · Lipolysis
AOD-9604

Modified GH fragment researched for adipose tissue effects.

Mechanism

A modified 16-amino-acid fragment (177–191) of human growth hormone, engineered to retain the lipolytic activity of GH without its growth or insulin-resistance effects. Research suggests it stimulates lipolysis and inhibits lipogenesis.

Research areas
  • Obesity (clinical trials did not meet endpoints)
  • Osteoarthritis / cartilage repair (current research direction)
  • Localized adipose research
Considerations
  • Not FDA-approved as a therapeutic.
  • Has GRAS status in some food contexts (Australia), not equivalent to drug approval.
Full AOD-9604 profile →
Metabolic · Incretin
Survodutide

GLP-1/glucagon dual agonist in late-stage obesity trials.

Mechanism

A dual agonist of the GLP-1 and glucagon receptors. The glucagon arm adds an energy-expenditure component on top of GLP-1's appetite and glycemic effects.

Research areas
  • Chronic weight management
  • MASH / fatty liver disease
  • Type 2 diabetes
Considerations
  • Investigational; not yet FDA-approved.
  • GI side effects are dose-limiting.
Full Survodutide profile →

AOD-9604 vs Survodutide — Key differences

  • Class: AOD-9604 is classified as Metabolic · Lipolysis, while Survodutide is Metabolic · Incretin.
  • Primary research focus: AOD-9604obesity (clinical trials did not meet endpoints); Survodutidechronic weight management.
  • Tag: Fat loss vs Weight loss.

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