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Statements on this site have not been evaluated by the FDA. Compounded preparations are subject to applicable state and federal regulations. Availability and eligibility vary.
Leuprolide (Lupron)
GnRH agonist used for prostate cancer, endometriosis, and precocious puberty.
Plain-Language Label Highlights
Brand names: Lupron, Eligard, Fensolvi
Advanced prostate cancer, endometriosis, uterine fibroids, central precocious puberty.
A depot injection that initially raises and then deeply lowers sex hormones (testosterone/estrogen) by shutting down the pituitary signal.
- •Hot flashes
- •Injection-site reactions
- •Bone pain (initial flare)
- •Fatigue
- •Mood changes
- •Initial testosterone/estrogen surge worsening symptoms
- •Bone density loss with long-term use
- •Cardiovascular and metabolic effects
- •QT prolongation
- •Pregnancy
- •Known hypersensitivity to GnRH analogs
- •Uncontrolled cardiac arrhythmia (caution)
Educational summary of the FDA prescribing information. Not a substitute for the full label or medical advice. Always discuss with a licensed prescriber.
Mechanism of Action
Synthetic nonapeptide GnRH agonist. Continuous administration desensitizes pituitary GnRH receptors, suppressing LH/FSH and downstream sex hormone production (medical castration).
Research Areas
Common Research Protocols
7.5 mg IM monthly, or 22.5 mg every 3 months.
Pediatric weight-based depot dosing.
Protocols summarized for educational reference from published research. Not dosing guidance.
Cited Research
Leuprolide in metastatic prostate cancer
Established equivalence to orchiectomy for androgen suppression.
Important Considerations
- •FDA-approved.
- •Initial testosterone flare; hot flashes, bone density loss with long-term use.
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Educational Information Only — Not Medical Advice
All content on this page is for educational and informational purposes only. It is not medical advice, diagnosis, or treatment. We make no claims that any peptide can diagnose, treat, cure, or prevent any disease. Peptides discussed are not FDA-approved for the indications listed unless explicitly stated otherwise.
Always consult a licensed healthcare provider before beginning any wellness protocol. Statements have not been evaluated by the FDA. Compounded preparations are subject to applicable state and federal regulations. Availability, eligibility, and pricing may vary.
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