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Degarelix (Firmagon)
GnRH antagonist providing immediate testosterone suppression in prostate cancer.
Plain-Language Label Highlights
Brand names: Firmagon
Advanced prostate cancer.
A GnRH blocker that quickly lowers testosterone without the early hormone flare seen with older drugs like leuprolide.
- •Hot flashes
- •Injection-site reactions (often painful nodules)
- •Weight gain
- •Fatigue
- •Elevated liver enzymes
- •QT prolongation
- •Severe injection-site reactions
- •Possible cardiovascular events
- •Known hypersensitivity to degarelix
- •Pre-existing long QT syndrome (caution)
Educational summary of the FDA prescribing information. Not a substitute for the full label or medical advice. Always discuss with a licensed prescriber.
Mechanism of Action
Synthetic decapeptide GnRH receptor antagonist. Blocks GnRH receptors directly, producing rapid suppression of LH, FSH, and testosterone without the initial flare seen with agonists.
Research Areas
Common Research Protocols
240 mg SC loading, then 80 mg SC monthly.
Protocols summarized for educational reference from published research. Not dosing guidance.
Cited Research
Degarelix vs leuprolide CS21 trial
Faster testosterone suppression and no testosterone surge vs leuprolide.
Important Considerations
- •FDA-approved.
- •Injection-site reactions common.
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Educational Information Only — Not Medical Advice
All content on this page is for educational and informational purposes only. It is not medical advice, diagnosis, or treatment. We make no claims that any peptide can diagnose, treat, cure, or prevent any disease. Peptides discussed are not FDA-approved for the indications listed unless explicitly stated otherwise.
Always consult a licensed healthcare provider before beginning any wellness protocol. Statements have not been evaluated by the FDA. Compounded preparations are subject to applicable state and federal regulations. Availability, eligibility, and pricing may vary.
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