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Statements on this site have not been evaluated by the FDA. Compounded preparations are subject to applicable state and federal regulations. Availability and eligibility vary.
Insulin Degludec (Tresiba)
Ultra-long-acting basal insulin with >42-hour duration.
Plain-Language Label Highlights
Brand names: Tresiba
Type 1 and type 2 diabetes — once-daily ultra-long basal insulin (>42 hr duration).
A flat, ultra-long-acting basal insulin with flexible timing — generally lower nighttime lows than older basal insulins.
- •Hypoglycemia
- •Injection-site reactions
- •Weight gain
- •Upper respiratory infection
- •Severe hypoglycemia
- •Hypokalemia
- •Hypersensitivity reactions
- •Fluid retention if combined with thiazolidinediones
- •During hypoglycemia
- •Known degludec hypersensitivity
Educational summary of the FDA prescribing information. Not a substitute for the full label or medical advice. Always discuss with a licensed prescriber.
Mechanism of Action
Insulin analog with a hexadecanedioic acid side chain at LysB29 that forms soluble multi-hexamers at the injection site, releasing monomers slowly for flat, prolonged action.
Research Areas
Common Research Protocols
Once-daily subcutaneous dose; timing flexibility within 8–40 hours between doses.
Protocols summarized for educational reference from published research. Not dosing guidance.
Cited Research
DEVOTE trial
Cardiovascular safety vs glargine with lower severe hypoglycemia.
Important Considerations
- •FDA-approved.
- •Steady state reached after ~3 days.
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Educational Information Only — Not Medical Advice
All content on this page is for educational and informational purposes only. It is not medical advice, diagnosis, or treatment. We make no claims that any peptide can diagnose, treat, cure, or prevent any disease. Peptides discussed are not FDA-approved for the indications listed unless explicitly stated otherwise.
Always consult a licensed healthcare provider before beginning any wellness protocol. Statements have not been evaluated by the FDA. Compounded preparations are subject to applicable state and federal regulations. Availability, eligibility, and pricing may vary.
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