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Histrelin (Supprelin LA / Vantas)
GnRH agonist implant for central precocious puberty and prostate cancer.
Plain-Language Label Highlights
Brand names: Supprelin LA, Vantas
Central precocious puberty (Supprelin LA) and advanced prostate cancer (Vantas).
A small under-the-skin implant replaced once a year that quietly lowers sex hormones the whole time.
- •Implant-site reactions (redness, soreness, bruising)
- •Hot flashes
- •Fatigue
- •Headache
- •Implant breakage at removal
- •Cardiovascular and metabolic effects with long-term use
- •Bone density loss
- •Pregnancy
- •Known hypersensitivity to GnRH analogs
Educational summary of the FDA prescribing information. Not a substitute for the full label or medical advice. Always discuss with a licensed prescriber.
Mechanism of Action
Synthetic nonapeptide GnRH agonist delivered via a subcutaneous hydrogel implant providing continuous release for 12 months, desensitizing the pituitary and suppressing sex steroids.
Research Areas
Common Research Protocols
50 mg SC implant in inner upper arm; replaced every 12 months.
Protocols summarized for educational reference from published research. Not dosing guidance.
Cited Research
Histrelin implant in CPP
Sustained suppression of pubertal progression with single annual implant.
Important Considerations
- •FDA-approved.
- •Implant site reactions and rare implant breakage at removal.
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Educational Information Only — Not Medical Advice
All content on this page is for educational and informational purposes only. It is not medical advice, diagnosis, or treatment. We make no claims that any peptide can diagnose, treat, cure, or prevent any disease. Peptides discussed are not FDA-approved for the indications listed unless explicitly stated otherwise.
Always consult a licensed healthcare provider before beginning any wellness protocol. Statements have not been evaluated by the FDA. Compounded preparations are subject to applicable state and federal regulations. Availability, eligibility, and pricing may vary.
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