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Bremelanotide (Vyleesi)
Melanocortin receptor agonist for hypoactive sexual desire disorder in premenopausal women.
Plain-Language Label Highlights
Brand names: Vyleesi
Acquired, generalized hypoactive sexual desire disorder (HSDD) in premenopausal women.
An on-demand injection that activates brain pathways tied to sexual desire. Used as needed before intimacy, not daily.
- •Nausea
- •Flushing
- •Headache
- •Vomiting
- •Cough
- •Transient increases in blood pressure
- •Focal hyperpigmentation (skin darkening)
- •Uncontrolled hypertension
- •Known cardiovascular disease
- •Pregnancy
Educational summary of the FDA prescribing information. Not a substitute for the full label or medical advice. Always discuss with a licensed prescriber.
Mechanism of Action
Cyclic 7-amino-acid synthetic analog of α-MSH that activates melanocortin receptors (primarily MC4R) in the CNS, modulating sexual desire pathways.
Research Areas
Common Research Protocols
1.75 mg SC at least 45 minutes before anticipated sexual activity (max 1 dose/24h, 8/month).
Protocols summarized for educational reference from published research. Not dosing guidance.
Cited Research
RECONNECT trials
Improved desire and reduced distress vs placebo in premenopausal HSDD.
Important Considerations
- •FDA-approved.
- •Nausea, flushing, transient BP elevation common.
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Educational Information Only — Not Medical Advice
All content on this page is for educational and informational purposes only. It is not medical advice, diagnosis, or treatment. We make no claims that any peptide can diagnose, treat, cure, or prevent any disease. Peptides discussed are not FDA-approved for the indications listed unless explicitly stated otherwise.
Always consult a licensed healthcare provider before beginning any wellness protocol. Statements have not been evaluated by the FDA. Compounded preparations are subject to applicable state and federal regulations. Availability, eligibility, and pricing may vary.
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