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Statements on this site have not been evaluated by the FDA. Compounded preparations are subject to applicable state and federal regulations. Availability and eligibility vary.
Plecanatide (Trulance) Peptide
Uroguanylin analog for chronic constipation.
What is Plecanatide (Trulance)?
Plecanatide (Trulance) is a gc-c agonist · gastrointestinal peptide studied for chronic idiopathic constipation and ibs-c. Below is an educational overview of Plecanatide (Trulance) peptide benefits, mechanism, common research protocols, dosage references, and known side effects.
Plain-Language Label Highlights
Brand names: Trulance
Chronic idiopathic constipation and IBS with constipation in adults.
A once-daily tablet that gently increases fluid in the gut to make bowel movements easier.
Do NOT give to children under 6 years — risk of severe dehydration.
- •Diarrhea
- •Sinus infection
- •Headache
- •Abdominal tenderness
- •Severe diarrhea with dehydration
- •Children under 6
- •Known or suspected GI obstruction
Educational summary of the FDA prescribing information. Not a substitute for the full label or medical advice. Always discuss with a licensed prescriber.
Plecanatide (Trulance) Mechanism of Action
Synthetic analog of human uroguanylin that activates guanylate cyclase-C in a pH-dependent manner, increasing intestinal fluid secretion and transit.
Plecanatide (Trulance) Research Areas & Benefits
Plecanatide (Trulance) Dosage & Common Research Protocols
3 mg orally once daily.
Protocols summarized for educational reference from published research. Not dosing guidance.
Plecanatide (Trulance) Studies & Cited Research
Plecanatide phase 3
Significantly improved complete spontaneous bowel movements vs placebo.
Why we trust this source: Published in a peer-reviewed scientific journal with editorial and reviewer oversight.
Citations are linked to PubMed, Google Scholar, and Crossref searches so you can verify the source independently. All references are reviewed during our editorial passes (last reviewed June 1, 2026).
Plecanatide (Trulance) Side Effects & Safety Considerations
- •FDA-approved.
- •Diarrhea most common adverse event.
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Educational Information Only — Not Medical Advice
All content on this page is for educational and informational purposes only. It is not medical advice, diagnosis, or treatment. We make no claims that any peptide can diagnose, treat, cure, or prevent any disease. Peptides discussed are not FDA-approved for the indications listed unless explicitly stated otherwise.
Always consult a licensed healthcare provider before beginning any wellness protocol. Statements have not been evaluated by the FDA. Compounded preparations are subject to applicable state and federal regulations. Availability, eligibility, and pricing may vary.
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