# Plecanatide (Trulance)

> Uroguanylin analog for chronic constipation.

Source: https://peptides.cafe/peptide/plecanatide
Category: GC-C Agonist · Gastrointestinal
Tag: FDA-Approved · GI

## Mechanism
Synthetic analog of human uroguanylin that activates guanylate cyclase-C in a pH-dependent manner, increasing intestinal fluid secretion and transit.

## Research areas
- Chronic idiopathic constipation
- IBS-C

## Common research protocols
- Oral: 3 mg orally once daily.

## Study summaries
- "Plecanatide phase 3" — American Journal of Gastroenterology (2017): Significantly improved complete spontaneous bowel movements vs placebo.

## Considerations
- FDA-approved.
- Diarrhea most common adverse event.

## Disclaimer
Educational content only. Not medical advice, diagnosis, or treatment. Most research peptides are not FDA-approved for human therapeutic use. Consult a licensed clinician before any use.