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Statements on this site have not been evaluated by the FDA. Compounded preparations are subject to applicable state and federal regulations. Availability and eligibility vary.
Cosyntropin (Cortrosyn) Peptide
Synthetic ACTH(1-24) for adrenal function testing.
What is Cosyntropin (Cortrosyn)?
Cosyntropin (Cortrosyn) is a diagnostic · endocrine peptide studied for primary and secondary adrenal insufficiency diagnosis. Below is an educational overview of Cosyntropin (Cortrosyn) peptide benefits, mechanism, common research protocols, dosage references, and known side effects.
Plain-Language Label Highlights
Brand names: Cortrosyn
Diagnostic testing for adrenal insufficiency (ACTH stimulation test).
A synthetic ACTH injection used to see whether the adrenal glands can produce cortisol when stimulated.
- •Flushing
- •Mild allergic reactions
- •Brief blood pressure changes
- •Severe allergic reactions including anaphylaxis (rare)
- •Known hypersensitivity to cosyntropin or ACTH
Educational summary of the FDA prescribing information. Not a substitute for the full label or medical advice. Always discuss with a licensed prescriber.
Cosyntropin (Cortrosyn) Mechanism of Action
Synthetic peptide containing the first 24 amino acids of ACTH — retains full corticotropic activity. Stimulates adrenal cortisol release for diagnostic testing.
Cosyntropin (Cortrosyn) Research Areas & Benefits
Cosyntropin (Cortrosyn) Dosage & Common Research Protocols
250 mcg IV/IM; cortisol measured at 30 and 60 min.
Protocols summarized for educational reference from published research. Not dosing guidance.
Cosyntropin (Cortrosyn) Studies & Cited Research
Low-dose vs standard cosyntropin stimulation
Comparison of 1 mcg vs 250 mcg testing for secondary adrenal insufficiency.
Why we trust this source: Source not yet matched to our reputable list. Treat as background information only.
Citations are linked to PubMed, Google Scholar, and Crossref searches so you can verify the source independently. All references are reviewed during our editorial passes (last reviewed June 1, 2026).
Cosyntropin (Cortrosyn) Side Effects & Safety Considerations
- •FDA-approved.
- •Single diagnostic dose; very well tolerated.
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Educational Information Only — Not Medical Advice
All content on this page is for educational and informational purposes only. It is not medical advice, diagnosis, or treatment. We make no claims that any peptide can diagnose, treat, cure, or prevent any disease. Peptides discussed are not FDA-approved for the indications listed unless explicitly stated otherwise.
Always consult a licensed healthcare provider before beginning any wellness protocol. Statements have not been evaluated by the FDA. Compounded preparations are subject to applicable state and federal regulations. Availability, eligibility, and pricing may vary.
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