# Cosyntropin (Cortrosyn)

> Synthetic ACTH(1-24) for adrenal function testing.

Source: https://peptides.cafe/peptide/cosyntropin
Category: Diagnostic · Endocrine
Tag: FDA-Approved · Diagnostic

## Mechanism
Synthetic peptide containing the first 24 amino acids of ACTH — retains full corticotropic activity. Stimulates adrenal cortisol release for diagnostic testing.

## Research areas
- Primary and secondary adrenal insufficiency diagnosis

## Common research protocols
- Standard test: 250 mcg IV/IM; cortisol measured at 30 and 60 min.

## Study summaries
- "Low-dose vs standard cosyntropin stimulation" — JCEM (2008): Comparison of 1 mcg vs 250 mcg testing for secondary adrenal insufficiency.

## Considerations
- FDA-approved.
- Single diagnostic dose; very well tolerated.

## Disclaimer
Educational content only. Not medical advice, diagnosis, or treatment. Most research peptides are not FDA-approved for human therapeutic use. Consult a licensed clinician before any use.