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This platform provides peer-reviewed research summaries and educational content about peptides for wellness and optimization purposes. Nothing on this site is intended as medical advice, diagnosis, or treatment. We do not claim any peptide can diagnose, treat, cure, or prevent any disease. Always consult a licensed healthcare provider before beginning any wellness protocol.

Statements on this site have not been evaluated by the FDA. Compounded preparations are subject to applicable state and federal regulations. Availability and eligibility vary.

Longevity · Senolytic

FOXO4-DRI

Senolytic peptide researched for clearance of senescent cells.

Mechanism of Action

A D-retro-inverso peptide that disrupts the FOXO4-p53 interaction inside senescent cells, selectively triggering their apoptosis while sparing healthy cells in preclinical models.

Research Areas

Senescent cell clearance

Tissue function in aged mice

Fibrotic disease models

Common Research Protocols

Intermittent research dosing

Cyclic IV/IP dosing in rodent aging studies.

Protocols summarized for educational reference from published research. Not dosing guidance.

Cited Research

[1]Cell·2017

Targeted apoptosis of senescent cells restores tissue homeostasis

Foundational paper establishing FOXO4-DRI as a selective senolytic in mice.

Important Considerations

•No human trials; safety and pharmacokinetics in humans unknown.
•Not FDA-approved.

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Educational Information Only — Not Medical Advice

All content on this page is for educational and informational purposes only. It is not medical advice, diagnosis, or treatment. We make no claims that any peptide can diagnose, treat, cure, or prevent any disease. Peptides discussed are not FDA-approved for the indications listed unless explicitly stated otherwise.

Always consult a licensed healthcare provider before beginning any wellness protocol. Statements have not been evaluated by the FDA. Compounded preparations are subject to applicable state and federal regulations. Availability, eligibility, and pricing may vary.

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