# FOXO4-DRI

> Senolytic peptide researched for clearance of senescent cells.

Source: https://peptides.cafe/peptide/foxo4-dri
Category: Longevity · Senolytic
Tag: Longevity · Senolytic

## Mechanism
A D-retro-inverso peptide that disrupts the FOXO4-p53 interaction inside senescent cells, selectively triggering their apoptosis while sparing healthy cells in preclinical models.

## Research areas
- Senescent cell clearance
- Tissue function in aged mice
- Fibrotic disease models

## Common research protocols
- Intermittent research dosing: Cyclic IV/IP dosing in rodent aging studies.

## Study summaries
- "Targeted apoptosis of senescent cells restores tissue homeostasis" — Cell (2017): Foundational paper establishing FOXO4-DRI as a selective senolytic in mice.

## Considerations
- No human trials; safety and pharmacokinetics in humans unknown.
- Not FDA-approved.

## Disclaimer
Educational content only. Not medical advice, diagnosis, or treatment. Most research peptides are not FDA-approved for human therapeutic use. Consult a licensed clinician before any use.