# VIP (Vasoactive Intestinal Peptide)

> Neuropeptide researched for immune modulation and lung protection.

Source: https://peptides.cafe/peptide/vip
Category: Immune · Respiratory
Tag: Immune · Respiratory

## Mechanism
A 28-amino-acid neuropeptide with broad immunomodulatory, anti-inflammatory, and bronchodilatory effects. Acts via VPAC1 and VPAC2 receptors to regulate T-cell function, macrophage polarization, and airway smooth muscle tone.

## Research areas
- Acute respiratory distress syndrome (ARDS)
- Chronic inflammatory conditions
- Autoimmune modulation
- Bronchial asthma and COPD

## Common research protocols
- Inhaled or IV research: Inhalation for pulmonary indications; IV for systemic immune modulation.

## Study summaries
- "VIP in acute respiratory distress syndrome" — Critical Care Medicine (2021): Demonstrated lung-protective effects in preclinical ARDS models.
- "VIP and immune tolerance" — Frontiers in Immunology (2019): Reviewed mechanisms of T-regulatory cell induction and immune homeostasis.

## Considerations
- Short half-life limits therapeutic utility; analogs in development.
- Not FDA-approved in native form.

## Disclaimer
Educational content only. Not medical advice, diagnosis, or treatment. Most research peptides are not FDA-approved for human therapeutic use. Consult a licensed clinician before any use.