# Vasopressin (Vasostrict)

> Nonapeptide hormone used for vasodilatory shock.

Source: https://peptides.cafe/peptide/vasopressin
Category: Vasopressor · Hormonal
Tag: FDA-Approved · Critical Care

## Mechanism
Endogenous nonapeptide that activates V1 vascular receptors to cause vasoconstriction and V2 renal receptors for water reabsorption. Used to raise blood pressure in catecholamine-resistant shock.

## Research areas
- Septic shock
- Cardiac arrest (historical)
- Diabetes insipidus

## Common research protocols
- Septic shock: 0.01–0.04 units/min IV infusion.

## Study summaries
- "VASST trial" — NEJM (2008): Vasopressin added to norepinephrine did not reduce mortality overall but benefited less severe septic shock.

## Considerations
- FDA-approved.
- Ischemic complications possible at high doses.

## Disclaimer
Educational content only. Not medical advice, diagnosis, or treatment. Most research peptides are not FDA-approved for human therapeutic use. Consult a licensed clinician before any use.