# Triptorelin (Trelstar)

> GnRH agonist depot for advanced prostate cancer.

Source: https://peptides.cafe/peptide/triptorelin
Category: GnRH Agonist · Oncology
Tag: FDA-Approved · Oncology

## Mechanism
Decapeptide GnRH agonist that initially stimulates then desensitizes pituitary GnRH receptors, suppressing LH, FSH, and downstream gonadal steroid production after the initial flare.

## Research areas
- Advanced prostate cancer
- Central precocious puberty (international)
- Endometriosis (international)

## Common research protocols
- Depot IM: 3.75 mg monthly, 11.25 mg every 3 months, or 22.5 mg every 6 months IM.

## Study summaries
- "Triptorelin vs leuprolide in prostate cancer" — Urology (2002): Comparable testosterone suppression efficacy.

## Considerations
- FDA-approved.
- Initial testosterone flare; consider antiandrogen pretreatment.
- Hot flashes, bone density loss with chronic use.

## Disclaimer
Educational content only. Not medical advice, diagnosis, or treatment. Most research peptides are not FDA-approved for human therapeutic use. Consult a licensed clinician before any use.