# Tiragratide

> Investigational triple hormone receptor agonist for metabolic disease.

Source: https://peptides.cafe/peptide/tiragratide
Category: Metabolic · Incretin
Tag: Metabolic

## Mechanism
An investigational peptide agonist targeting GLP-1, GIP, and glucagon receptors. Similar mechanism to retatrutide, designed to maximize weight loss while preserving lean mass through multi-pathway metabolic modulation.

## Research areas
- Obesity and metabolic syndrome
- Type 2 diabetes glycemic control
- NAFLD and liver fat reduction

## Common research protocols
- Weekly subcutaneous research: Once-weekly dosing in Phase 2 and 3 clinical trials.

## Study summaries
- "Tiragratide Phase 2 trial in obesity" — Diabetes Care (2025): Demonstrated significant weight reduction with favorable GI tolerability profile.

## Considerations
- Investigational; not yet FDA-approved.
- Requires physician oversight in clinical trials.

## Disclaimer
Educational content only. Not medical advice, diagnosis, or treatment. Most research peptides are not FDA-approved for human therapeutic use. Consult a licensed clinician before any use.