# TB-500 > Synthetic fragment of Thymosin Beta-4 studied for tissue and vascular repair. Source: https://peptides.cafe/peptide/tb-500 Category: Tissue Repair · Vascular Tag: Recovery ## Mechanism A synthetic peptide fragment of Thymosin Beta-4 (Tβ4). Research suggests it upregulates actin, promotes cell migration, angiogenesis, and modulates inflammation — supporting repair in muscle, tendon, cardiac, and corneal tissue models. ## Research areas - Muscle and tendon repair - Cardiac tissue recovery (preclinical) - Corneal and dermal wound healing - Hair follicle stem cell activation ## Common research protocols - Loading + maintenance research: Higher-frequency subcutaneous dosing over 4–6 weeks, then lower maintenance frequency in animal recovery models. ## Study summaries - "Thymosin beta-4: a multi-functional regenerative peptide" — Expert Opinion on Biological Therapy (2015): Review of Tβ4's roles in repair, angiogenesis, and anti-inflammation. ## Considerations - Not FDA-approved; banned by WADA. - Most evidence is preclinical. ## Disclaimer Educational content only. Not medical advice, diagnosis, or treatment. Most research peptides are not FDA-approved for human therapeutic use. Consult a licensed clinician before any use.