# Sincalide (Kinevac)

> Synthetic C-terminal octapeptide of cholecystokinin for gallbladder imaging.

Source: https://peptides.cafe/peptide/sincalide
Category: CCK Analog · Diagnostics
Tag: FDA-Approved · Diagnostics

## Mechanism
Synthetic CCK-8 that binds CCK-A receptors on gallbladder smooth muscle, triggering contraction; used to assess gallbladder ejection fraction in cholescintigraphy.

## Research areas
- Gallbladder ejection fraction (HIDA scan)
- Pancreatic secretion testing
- Small bowel transit imaging

## Common research protocols
- Slow IV infusion: 0.02 mcg/kg IV infused over 60 minutes (preferred to bolus to limit cramping).

## Study summaries
- "Standardized sincalide cholescintigraphy guideline" — J Nucl Med (2010): Established 60-minute infusion as optimal for reproducible GBEF.

## Considerations
- FDA-approved.
- Abdominal cramping, nausea, diarrhea common; contraindicated in suspected gallstone obstruction.

## Disclaimer
Educational content only. Not medical advice, diagnosis, or treatment. Most research peptides are not FDA-approved for human therapeutic use. Consult a licensed clinician before any use.