# Sermorelin

> Shorter-acting GHRH analog used in clinical GH research.

Source: https://peptides.cafe/peptide/sermorelin
Category: Growth Hormone Axis
Tag: Growth hormone

## Mechanism
A synthetic 29-amino-acid analog representing the active fragment of endogenous GHRH. Stimulates the pituitary to release GH in a physiologic, pulsatile pattern. Previously FDA-approved (Geref) for pediatric GH deficiency diagnosis before discontinuation for commercial reasons.

## Research areas
- Adult GH deficiency
- Pediatric short stature (historical)
- Sleep quality and body composition in aging

## Common research protocols
- Evening subcutaneous research: Bedtime subcutaneous dosing to align with natural nocturnal GH pulse.

## Study summaries
- "Sermorelin in adult growth hormone deficiency" — Endocrine Practice (2010): Reviewed efficacy on body composition, energy, and sleep markers.

## Considerations
- No longer commercially available as an FDA-approved drug; available via compounding.
- Requires physician oversight.
- Banned in competitive sport.

## Disclaimer
Educational content only. Not medical advice, diagnosis, or treatment. Most research peptides are not FDA-approved for human therapeutic use. Consult a licensed clinician before any use.