# Semax

> Russian-origin peptide studied for focus and neuroprotection.

Source: https://peptides.cafe/peptide/semax
Category: Nootropic · Neuroprotection
Tag: Cognition

## Mechanism
A synthetic heptapeptide derived from ACTH(4-10). Research suggests it modulates BDNF and NGF expression, dopaminergic and serotonergic tone, and shows neuroprotective effects in ischemia models.

## Research areas
- BDNF/NGF upregulation
- Ischemic stroke recovery (clinical use in Russia)
- Attention and cognitive performance
- Anxiolytic-style effects

## Common research protocols
- Intranasal research: Standard route in published Russian clinical literature.

## Study summaries
- "Semax in the treatment of ischemic stroke" — Zhurnal Nevrologii i Psikhiatrii (2018): Reported improved neurological recovery scores in acute ischemic stroke.
- "Semax and its analogs in neuroprotection" — Molecular Neurobiology (2020): Review of neurotrophic and antioxidant mechanisms.

## Considerations
- Approved as a medication in Russia; not FDA-approved in the US.
- Most clinical literature is in Russian.

## Disclaimer
Educational content only. Not medical advice, diagnosis, or treatment. Most research peptides are not FDA-approved for human therapeutic use. Consult a licensed clinician before any use.