# Selank > Anxiolytic-style peptide researched for stress modulation. Source: https://peptides.cafe/peptide/selank Category: Anxiolytic · Nootropic Tag: Calm · Cognition ## Mechanism A synthetic analog of the immunomodulatory peptide tuftsin. Research suggests it modulates GABAergic and serotonergic systems and influences expression of brain-derived neurotrophic factor without the sedation or dependence profile of benzodiazepines. ## Research areas - Generalized anxiety models - BDNF expression - Immune modulation - Memory and learning in rodent models ## Common research protocols - Intranasal research: Primary administration route in Russian clinical studies. ## Study summaries - "Selank in generalized anxiety disorder" — Zhurnal Nevrologii i Psikhiatrii (2008): Comparable anxiolytic effect to medazepam without sedation or withdrawal. ## Considerations - Not FDA-approved. - Most studies are Russian clinical literature. ## Disclaimer Educational content only. Not medical advice, diagnosis, or treatment. Most research peptides are not FDA-approved for human therapeutic use. Consult a licensed clinician before any use.