# Nesiritide (Natrecor)

> Recombinant BNP for acute decompensated heart failure.

Source: https://peptides.cafe/peptide/nesiritide
Category: Natriuretic Peptide · Cardiology
Tag: FDA-Approved · Cardiology

## Mechanism
Recombinant human B-type natriuretic peptide that binds natriuretic peptide receptors to cause vasodilation, natriuresis, and reduction of preload/afterload in decompensated heart failure.

## Research areas
- Acute decompensated heart failure

## Common research protocols
- Infusion: 2 mcg/kg IV bolus + 0.01 mcg/kg/min infusion.

## Study summaries
- "ASCEND-HF trial" — NEJM (2011): Modest dyspnea improvement; no mortality benefit.

## Considerations
- FDA-approved.
- Hypotension common; renal monitoring needed.

## Disclaimer
Educational content only. Not medical advice, diagnosis, or treatment. Most research peptides are not FDA-approved for human therapeutic use. Consult a licensed clinician before any use.