# Melanotan II

> Melanocortin agonist researched for tanning response and libido.

Source: https://peptides.cafe/peptide/melanotan-ii
Category: Pigmentation · Melanocortin
Tag: Skin · Pigmentation

## Mechanism
A non-selective melanocortin receptor agonist that stimulates eumelanin production via MC1R and influences appetite, libido, and erectile function via MC3R/MC4R.

## Research areas
- UV-independent pigmentation
- Erythropoietic protoporphyria (related compound, afamelanotide)
- Sexual function (overlap with PT-141)

## Common research protocols
- Loading + maintenance research: Low-dose subcutaneous loading until desired pigmentation, then maintenance dosing.

## Study summaries
- "Melanotan and melanocortin receptor pharmacology" — Peptides (2005): Reviewed pigmentation and behavioral effects of MT-II in animal and human studies.

## Considerations
- Not FDA-approved.
- Risk of new or changing nevi — dermatologic monitoring is essential.
- Common side effects: nausea, flushing, spontaneous erections, appetite suppression.

## Disclaimer
Educational content only. Not medical advice, diagnosis, or treatment. Most research peptides are not FDA-approved for human therapeutic use. Consult a licensed clinician before any use.