# Melanotan I (Afamelanotide)

> Selective MC1R agonist FDA-approved for erythropoietic protoporphyria.

Source: https://peptides.cafe/peptide/melanotan-i
Category: Pigmentation · Melanocortin
Tag: Skin · Pigmentation

## Mechanism
A selective melanocortin-1 receptor (MC1R) agonist that stimulates eumelanin production in melanocytes. FDA-approved (Scenesse) as an implant for erythropoietic protoporphyria, a rare light-sensitive disorder.

## Research areas
- Erythropoietic protoporphyria (FDA-approved)
- UV-independent tanning (research)
- Photoprotection in photosensitivity disorders

## Common research protocols
- Implant clinical use: Subcutaneous implant every 2 months in approved indication.

## Study summaries
- "Afamelanotide for erythropoietic protoporphyria" — New England Journal of Medicine (2015): Phase 3 trials showed significant pain reduction and sun tolerance.

## Considerations
- FDA-approved for EPP via implant formulation only.
- Not approved for cosmetic tanning.
- Monitoring for new/changing moles recommended.

## Disclaimer
Educational content only. Not medical advice, diagnosis, or treatment. Most research peptides are not FDA-approved for human therapeutic use. Consult a licensed clinician before any use.