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Statements on this site have not been evaluated by the FDA. Compounded preparations are subject to applicable state and federal regulations. Availability and eligibility vary.
Melanotan I (Afamelanotide)
Selective MC1R agonist FDA-approved for erythropoietic protoporphyria.
Plain-Language Label Highlights
Brand names: Scenesse (afamelanotide)
Increasing pain-free light exposure in adults with erythropoietic protoporphyria (EPP).
A small implant placed under the skin every two months that boosts protective skin pigment so people with EPP can tolerate light.
- •Implant-site reactions
- •Headache
- •Nausea
- •Skin darkening
- •New or darkening moles
- •Skin cancer risk — annual full-skin exams required
- •Hyperpigmentation
- •Allergic reactions
- •Hepatic impairment
- •History of melanoma or current suspicious skin lesions
- •Pregnancy/lactation (limited data)
Educational summary of the FDA prescribing information. Not a substitute for the full label or medical advice. Always discuss with a licensed prescriber.
Mechanism of Action
A selective melanocortin-1 receptor (MC1R) agonist that stimulates eumelanin production in melanocytes. FDA-approved (Scenesse) as an implant for erythropoietic protoporphyria, a rare light-sensitive disorder.
Research Areas
Common Research Protocols
Subcutaneous implant every 2 months in approved indication.
Protocols summarized for educational reference from published research. Not dosing guidance.
Cited Research
Afamelanotide for erythropoietic protoporphyria
Phase 3 trials showed significant pain reduction and sun tolerance.
Important Considerations
- •FDA-approved for EPP via implant formulation only.
- •Not approved for cosmetic tanning.
- •Monitoring for new/changing moles recommended.
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Educational Information Only — Not Medical Advice
All content on this page is for educational and informational purposes only. It is not medical advice, diagnosis, or treatment. We make no claims that any peptide can diagnose, treat, cure, or prevent any disease. Peptides discussed are not FDA-approved for the indications listed unless explicitly stated otherwise.
Always consult a licensed healthcare provider before beginning any wellness protocol. Statements have not been evaluated by the FDA. Compounded preparations are subject to applicable state and federal regulations. Availability, eligibility, and pricing may vary.
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