# Macimorelin (Macrilen)

> Oral ghrelin agonist for diagnosing adult growth hormone deficiency.

Source: https://peptides.cafe/peptide/macimorelin
Category: GH Secretagogue · Diagnostics
Tag: FDA-Approved · Diagnostics

## Mechanism
Oral ghrelin receptor (GHSR-1a) agonist that stimulates pituitary GH release; peak GH response is measured to evaluate adult GH deficiency.

## Research areas
- Diagnostic test for adult GH deficiency

## Common research protocols
- Single oral dose: 0.5 mg/kg dissolved in water, fasted; serum GH measured at 30, 45, 60, 90 minutes.

## Study summaries
- "Macimorelin vs ITT for AGHD" — JCEM (2018): Non-inferior diagnostic accuracy to insulin tolerance test with better tolerability.

## Considerations
- FDA-approved.
- Avoid with QT-prolonging drugs.
- Hold strong CYP3A4 inducers prior to test.

## Disclaimer
Educational content only. Not medical advice, diagnosis, or treatment. Most research peptides are not FDA-approved for human therapeutic use. Consult a licensed clinician before any use.