# Lonapegsomatropin (Skytrofa)

> Long-acting pegylated growth hormone, once-weekly.

Source: https://peptides.cafe/peptide/lonapegsomatropin
Category: GH Analog · Endocrine
Tag: FDA-Approved · Endocrine

## Mechanism
Prodrug of somatropin with a transient PEG linker that releases unmodified GH over ~1 week, providing once-weekly dosing for pediatric GH deficiency.

## Research areas
- Pediatric growth hormone deficiency

## Common research protocols
- Weekly SC: 0.24 mg/kg SC once weekly.

## Study summaries
- "heiGHt trial" — JCEM (2021): Non-inferior annualized height velocity vs daily somatropin.

## Considerations
- FDA-approved.
- Same class warnings as daily GH (intracranial hypertension, scoliosis progression, glucose intolerance).

## Disclaimer
Educational content only. Not medical advice, diagnosis, or treatment. Most research peptides are not FDA-approved for human therapeutic use. Consult a licensed clinician before any use.