# Larazotide

> Tight junction regulator studied for celiac disease.

Source: https://peptides.cafe/peptide/larazotide
Category: Gastrointestinal · Barrier
Tag: Gut

## Mechanism
An octapeptide zonulin antagonist that helps maintain intestinal tight junction integrity, reducing paracellular permeability triggered by gluten in celiac disease.

## Research areas
- Celiac disease (Phase 3 completed)
- Intestinal barrier function ('leaky gut' research)
- Environmental enteropathy

## Common research protocols
- Oral pre-meal dosing: Oral administration before meals in celiac clinical trials.

## Study summaries
- "Larazotide acetate for persistent symptoms of celiac disease" — Gastroenterology (2015): Reduced symptom severity in gluten-exposed celiac patients on gluten-free diet.

## Considerations
- Not yet FDA-approved.
- Investigational; physician oversight required.

## Disclaimer
Educational content only. Not medical advice, diagnosis, or treatment. Most research peptides are not FDA-approved for human therapeutic use. Consult a licensed clinician before any use.