# KPV

> Tripeptide fragment of α-MSH researched for inflammation.

Source: https://peptides.cafe/peptide/kpv
Category: Gastrointestinal · Anti-inflammatory
Tag: Gut · Anti-inflammatory

## Mechanism
The C-terminal tripeptide (Lys-Pro-Val) of α-MSH. Research suggests anti-inflammatory effects via melanocortin pathways and intracellular NF-κB modulation — without the pigmentation effects of full-length α-MSH.

## Research areas
- Inflammatory bowel disease models
- Atopic dermatitis (topical research)
- Mast cell stabilization

## Common research protocols
- Oral or topical research: Oral capsule for gut research; topical for dermatologic models.

## Study summaries
- "KPV reduces colonic inflammation in IBD models" — Gastroenterology (2009): Oral KPV nanoparticles reduced inflammatory markers in mouse colitis.

## Considerations
- Not FDA-approved.
- Most evidence is preclinical.

## Disclaimer
Educational content only. Not medical advice, diagnosis, or treatment. Most research peptides are not FDA-approved for human therapeutic use. Consult a licensed clinician before any use.