# Kisspeptin-10

> Upstream regulator of GnRH studied for reproductive endocrinology.

Source: https://peptides.cafe/peptide/kisspeptin-10
Category: Hormonal · HPG Axis
Tag: Hormonal · HPG axis

## Mechanism
A peptide product of the KISS1 gene that acts upstream of GnRH neurons via the KISS1R/GPR54 receptor. Research demonstrates robust LH (and indirectly testosterone/estradiol) responses without desensitizing the pituitary.

## Research areas
- Hypothalamic amenorrhea
- Male hypogonadism research
- IVF triggering protocols

## Common research protocols
- Subcutaneous research: Investigational subcutaneous or IV dosing in reproductive endocrinology studies.

## Study summaries
- "Kisspeptin-10 in reproductive endocrinology" — Journal of Clinical Endocrinology & Metabolism (2014): Restored LH pulsatility in women with hypothalamic amenorrhea.

## Considerations
- Investigational; not FDA-approved.
- Effects on the HPG axis warrant physician oversight.

## Disclaimer
Educational content only. Not medical advice, diagnosis, or treatment. Most research peptides are not FDA-approved for human therapeutic use. Consult a licensed clinician before any use.