# Ipamorelin

> Selective GH secretagogue with a clean research profile.

Source: https://peptides.cafe/peptide/ipamorelin
Category: Growth Hormone Axis
Tag: Recovery · Sleep

## Mechanism
A selective ghrelin/GHS-R1a receptor agonist that stimulates GH release with minimal effect on cortisol, prolactin, or appetite — distinguishing it from older secretagogues like GHRP-6.

## Research areas
- Endogenous GH release without cortisol elevation
- Sleep quality and recovery markers
- Lean tissue retention in catabolic states

## Common research protocols
- Evening administration: Studied in evening dosing to align with natural nocturnal GH pulse.
- Stacked with CJC-1295: Common pairing in research to combine GHRH + ghrelin-mimetic signaling.

## Study summaries
- "Ipamorelin, the first selective growth hormone secretagogue" — European Journal of Endocrinology (1998): Characterized selectivity for GH release without affecting ACTH, cortisol, or prolactin.

## Considerations
- Generally well tolerated in research; long-term human safety data are limited.
- Not FDA-approved.
- Use in sport is prohibited (WADA).

## Disclaimer
Educational content only. Not medical advice, diagnosis, or treatment. Most research peptides are not FDA-approved for human therapeutic use. Consult a licensed clinician before any use.