# Insulin Lispro (Humalog)

> Rapid-acting mealtime insulin analog.

Source: https://peptides.cafe/peptide/insulin-lispro
Category: Insulin Analog · Endocrine
Tag: FDA-Approved · Diabetes

## Mechanism
Recombinant insulin analog with reversed lysine and proline at B28/B29, reducing self-association so it acts within ~15 minutes for postprandial glucose control.

## Research areas
- Prandial coverage in T1D/T2D
- Insulin pump therapy
- Hyperglycemic crises (with caution)

## Common research protocols
- Mealtime SC: Subcutaneous dose 0–15 minutes before meals, dosed by carbohydrate intake and correction factor.

## Study summaries
- "Lispro pharmacokinetics vs regular insulin" — Diabetes (1994): Faster onset and shorter duration improved postprandial control.

## Considerations
- FDA-approved.
- Hypoglycemia risk if meal delayed or skipped.

## Disclaimer
Educational content only. Not medical advice, diagnosis, or treatment. Most research peptides are not FDA-approved for human therapeutic use. Consult a licensed clinician before any use.