# IGF-1 LR3

> Long-acting IGF-1 analog studied for anabolic and recovery effects.

Source: https://peptides.cafe/peptide/igf-1-lr3
Category: Growth Factor
Tag: Growth · Recovery

## Mechanism
A modified form of insulin-like growth factor-1 with an Arg3 substitution and N-terminal extension that reduces binding to IGFBPs, dramatically extending its half-life and free fraction in circulation.

## Research areas
- Muscle protein synthesis (preclinical)
- Tissue repair signaling
- Cell-culture growth applications

## Common research protocols
- Subcutaneous research dosing: Investigational subcutaneous administration in animal anabolic studies.

## Study summaries
- "Long-R3-IGF-I pharmacology and IGFBP interactions" — Journal of Endocrinology (2001): Characterized extended half-life and bioactivity vs native IGF-1.

## Considerations
- Hypoglycemia risk via insulin-receptor cross-activity.
- Not FDA-approved for human therapeutic use; banned by WADA.

## Disclaimer
Educational content only. Not medical advice, diagnosis, or treatment. Most research peptides are not FDA-approved for human therapeutic use. Consult a licensed clinician before any use.