# Goserelin (Zoladex)

> GnRH agonist implant for hormone-sensitive cancers.

Source: https://peptides.cafe/peptide/goserelin
Category: GnRH Agonist · Hormonal
Tag: FDA-Approved · Oncology

## Mechanism
Decapeptide GnRH agonist delivered via biodegradable subcutaneous implant. Suppresses gonadotropin and sex hormone production through pituitary desensitization.

## Research areas
- Prostate cancer
- Breast cancer (premenopausal)
- Endometriosis

## Common research protocols
- Implant: 3.6 mg SC monthly or 10.8 mg SC every 12 weeks.

## Study summaries
- "ZIPP trial" — Lancet Oncology (2005): Adjuvant goserelin improved outcomes in premenopausal breast cancer.

## Considerations
- FDA-approved.
- Testosterone/estrogen flare; menopausal symptoms.

## Disclaimer
Educational content only. Not medical advice, diagnosis, or treatment. Most research peptides are not FDA-approved for human therapeutic use. Consult a licensed clinician before any use.