# Gonadorelin

> Synthetic GnRH used to stimulate LH/FSH and testicular function.

Source: https://peptides.cafe/peptide/gonadorelin
Category: Hormonal · HPG Axis
Tag: Hormonal · HPG axis

## Mechanism
A synthetic decapeptide identical to endogenous gonadotropin-releasing hormone (GnRH). Pulsatile administration stimulates the anterior pituitary to release LH and FSH, supporting endogenous testosterone production and testicular size.

## Research areas
- HPG axis support during/after TRT
- Hypogonadotropic hypogonadism diagnosis
- Fertility-preservation protocols

## Common research protocols
- Pulsatile subcutaneous research: Small-frequency subcutaneous dosing to mimic the physiologic GnRH pulse.

## Study summaries
- "Pulsatile GnRH in hypogonadotropic hypogonadism" — Journal of Clinical Endocrinology & Metabolism (1997): Restored LH/FSH and fertility in select hypogonadal men.

## Considerations
- Requires physician oversight, especially alongside TRT.
- Continuous (non-pulsatile) administration suppresses the axis instead of stimulating it.

## Disclaimer
Educational content only. Not medical advice, diagnosis, or treatment. Most research peptides are not FDA-approved for human therapeutic use. Consult a licensed clinician before any use.