# Glucagon (GlucaGen / Baqsimi)

> 29-amino-acid peptide hormone for severe hypoglycemia.

Source: https://peptides.cafe/peptide/glucagon-rx
Category: Counter-regulatory Hormone · Endocrine
Tag: FDA-Approved · Emergency

## Mechanism
Pancreatic alpha-cell peptide hormone that activates hepatic glucagon receptors, stimulating glycogenolysis and gluconeogenesis to raise blood glucose; also relaxes GI smooth muscle (used in radiology).

## Research areas
- Severe hypoglycemia (T1D/T2D)
- Beta-blocker overdose
- GI motility (imaging adjunct)

## Common research protocols
- Hypoglycemia (IM): 1 mg IM/SC; pediatric weight-based.
- Nasal (Baqsimi): 3 mg single intranasal dose.

## Study summaries
- "Nasal glucagon (Baqsimi) trials" — Diabetes Care (2016): Non-inferior glucose response vs IM glucagon, easier administration.

## Considerations
- FDA-approved.
- Nausea/vomiting common after recovery.

## Disclaimer
Educational content only. Not medical advice, diagnosis, or treatment. Most research peptides are not FDA-approved for human therapeutic use. Consult a licensed clinician before any use.