# Epitalon

> Pineal peptide researched for telomere and circadian support.

Source: https://peptides.cafe/peptide/epitalon
Category: Longevity · Circadian
Tag: Longevity

## Mechanism
A synthetic tetrapeptide (Ala-Glu-Asp-Gly) modeled on epithalamin, a pineal gland extract. Research from Russian gerontology groups has examined effects on telomerase activity, melatonin rhythm, and lifespan in rodent and limited human cohorts.

## Research areas
- Telomerase activity (in vitro)
- Circadian and melatonin rhythm
- Age-related morbidity in long-term Russian cohort studies

## Common research protocols
- Cyclic research dosing: Short subcutaneous cycles (e.g., 10–20 days) in Russian gerontology protocols.

## Study summaries
- "Effect of Epitalon on telomere length in human somatic cells" — Bulletin of Experimental Biology and Medicine (2003): Reported telomerase induction and telomere elongation in cultured cells.
- "Long-term Epitalon administration in elderly subjects" — Neuroendocrinology Letters (2003): Observed reduction in age-related mortality markers over multi-year follow-up.

## Considerations
- Most research is Russian and methodologically heterogeneous.
- Not FDA-approved.
- Independent replication is limited.

## Disclaimer
Educational content only. Not medical advice, diagnosis, or treatment. Most research peptides are not FDA-approved for human therapeutic use. Consult a licensed clinician before any use.