# Dihexa

> Angiotensin IV analog researched for synaptogenesis.

Source: https://peptides.cafe/peptide/dihexa
Category: Nootropic · Synaptogenesis
Tag: Cognition

## Mechanism
A hexapeptide derived from angiotensin IV that crosses the blood-brain barrier and potentiates hepatocyte growth factor (HGF) / c-Met signaling, associated with new synapse formation in preclinical models.

## Research areas
- Synaptogenesis and dendritic spine density
- Alzheimer's and cognitive aging models
- Memory consolidation in rodents

## Common research protocols
- Oral/transdermal research: Investigational dosing in animal cognition studies; human data are minimal.

## Study summaries
- "Dihexa, a potent procognitive HGF mimetic" — Journal of Pharmacology and Experimental Therapeutics (2012): Robust improvements in spatial learning in aged rodent models.

## Considerations
- No human clinical trial data; theoretical proliferation concerns via HGF/c-Met.
- Not FDA-approved.

## Disclaimer
Educational content only. Not medical advice, diagnosis, or treatment. Most research peptides are not FDA-approved for human therapeutic use. Consult a licensed clinician before any use.