# Desmopressin (DDAVP)

> Synthetic vasopressin analog for diabetes insipidus and nocturnal enuresis.

Source: https://peptides.cafe/peptide/desmopressin
Category: Vasopressin Analog · Hormonal
Tag: FDA-Approved · Endocrine

## Mechanism
Synthetic analog of arginine vasopressin with enhanced antidiuretic activity and negligible vasopressor effect. Acts on renal V2 receptors to increase water reabsorption; also increases factor VIII and vWF release.

## Research areas
- Central diabetes insipidus
- Primary nocturnal enuresis
- Hemophilia A
- von Willebrand disease type 1

## Common research protocols
- Diabetes insipidus: Intranasal 10–40 mcg/day or oral 0.1–0.8 mg/day.
- Enuresis: Oral 0.2 mg at bedtime.

## Study summaries
- "Desmopressin for nocturnal enuresis" — Journal of Urology (2006): Effective short-term reduction of bedwetting in children.

## Considerations
- FDA-approved.
- Risk of hyponatremia — limit fluids around dosing.

## Disclaimer
Educational content only. Not medical advice, diagnosis, or treatment. Most research peptides are not FDA-approved for human therapeutic use. Consult a licensed clinician before any use.