# Daptomycin (Cubicin)

> Cyclic lipopeptide antibiotic for serious Gram-positive infections.

Source: https://peptides.cafe/peptide/daptomycin
Category: Lipopeptide Antibiotic · Infectious Disease
Tag: FDA-Approved · Antibiotic

## Mechanism
13-amino-acid cyclic lipopeptide that inserts into Gram-positive bacterial membranes in a calcium-dependent manner, causing rapid membrane depolarization and bactericidal activity.

## Research areas
- MRSA bacteremia
- Right-sided endocarditis
- Complicated skin/soft tissue infections

## Common research protocols
- Standard: 4–6 mg/kg IV once daily (higher doses 8–10 mg/kg used off-label).

## Study summaries
- "Daptomycin vs standard therapy for S. aureus bacteremia" — NEJM (2006): Non-inferior to standard therapy for S. aureus bacteremia/endocarditis.

## Considerations
- FDA-approved.
- Monitor CPK; not effective for pneumonia (inactivated by surfactant).

## Disclaimer
Educational content only. Not medical advice, diagnosis, or treatment. Most research peptides are not FDA-approved for human therapeutic use. Consult a licensed clinician before any use.