# Bivalirudin (Angiomax)

> Direct thrombin inhibitor peptide for PCI anticoagulation.

Source: https://peptides.cafe/peptide/bivalirudin
Category: Anticoagulant · Cardiology
Tag: FDA-Approved · Cardiology

## Mechanism
Synthetic 20-amino-acid peptide that reversibly and directly inhibits thrombin (both circulating and fibrin-bound). Used for anticoagulation during percutaneous coronary intervention.

## Research areas
- PCI anticoagulation
- Heparin-induced thrombocytopenia

## Common research protocols
- PCI: 0.75 mg/kg IV bolus + 1.75 mg/kg/h infusion during procedure.

## Study summaries
- "HORIZONS-AMI trial" — NEJM (2008): Reduced bleeding vs heparin + GP IIb/IIIa in primary PCI.

## Considerations
- FDA-approved.
- Renal dose adjustment required.

## Disclaimer
Educational content only. Not medical advice, diagnosis, or treatment. Most research peptides are not FDA-approved for human therapeutic use. Consult a licensed clinician before any use.