# Apelin

> Endogenous peptide researched for heart and metabolic function.

Source: https://peptides.cafe/peptide/apelin
Category: Cardiovascular · Metabolic
Tag: Cardiovascular · Metabolic

## Mechanism
An endogenous peptide ligand for the APJ receptor, widely expressed in cardiovascular and metabolic tissues. Research indicates roles in cardiac contractility, angiogenesis, blood pressure regulation, and insulin sensitivity.

## Research areas
- Heart failure and cardiac contractility
- Pulmonary arterial hypertension
- Insulin sensitivity and glucose uptake
- Angiogenesis and vascular repair

## Common research protocols
- IV infusion research: Intravenous administration in acute cardiac and pulmonary research.

## Study summaries
- "Apelin in heart failure: a new therapeutic target" — Journal of the American College of Cardiology (2019): Reviewed cardioprotective mechanisms and therapeutic potential in heart failure.
- "Apelin improves insulin sensitivity in obese models" — Diabetes (2014): Enhanced glucose uptake and insulin signaling in adipose and muscle tissue.

## Considerations
- Primarily preclinical and early clinical research.
- Not FDA-approved for any indication.

## Disclaimer
Educational content only. Not medical advice, diagnosis, or treatment. Most research peptides are not FDA-approved for human therapeutic use. Consult a licensed clinician before any use.