# Angiotensin-(1-7)

> Counter-regulatory peptide of the renin-angiotensin system.

Source: https://peptides.cafe/peptide/angiotensin-1-7
Category: Cardiovascular · Anti-inflammatory
Tag: Cardiovascular · Anti-inflammatory

## Mechanism
A heptapeptide of the renin-angiotensin system that acts on Mas receptors. Research demonstrates counter-regulatory effects to angiotensin II, promoting vasodilation, anti-inflammatory signaling, and anti-fibrotic effects in cardiovascular and renal tissues.

## Research areas
- Pulmonary hypertension and fibrosis
- Heart failure with preserved ejection fraction
- Acute lung injury and ARDS
- Diabetic nephropathy

## Common research protocols
- IV/subcutaneous research: Investigational dosing in cardiopulmonary and renal disease models.

## Study summaries
- "Angiotensin-(1-7) as a therapeutic in lung disease" — American Journal of Respiratory and Critical Care Medicine (2020): Demonstrated protective effects in acute lung injury and pulmonary fibrosis models.
- "Mas receptor activation in cardiovascular protection" — Circulation Research (2018): Reviewed anti-inflammatory and anti-fibrotic mechanisms in cardiac tissue.

## Considerations
- Investigational; not FDA-approved.
- Interaction with ACE inhibitors and ARBs requires careful study design.

## Disclaimer
Educational content only. Not medical advice, diagnosis, or treatment. Most research peptides are not FDA-approved for human therapeutic use. Consult a licensed clinician before any use.