# Abaloparatide (Tymlos)

> PTHrP analog for postmenopausal osteoporosis.

Source: https://peptides.cafe/peptide/abaloparatide
Category: PTHrP Analog · Anabolic Bone
Tag: FDA-Approved · Bone

## Mechanism
Synthetic 34-amino-acid analog of parathyroid hormone-related protein (PTHrP). Selectively activates the PTH1 receptor RG conformation, favoring osteoanabolic effects over resorption.

## Research areas
- Postmenopausal osteoporosis
- Male osteoporosis

## Common research protocols
- Daily injection: 80 mcg SC once daily for up to 2 years.

## Study summaries
- "ACTIVE trial" — JAMA (2016): Reduced new vertebral and nonvertebral fractures vs placebo and teriparatide.

## Considerations
- FDA-approved.
- Orthostatic hypotension possible after dosing.

## Disclaimer
Educational content only. Not medical advice, diagnosis, or treatment. Most research peptides are not FDA-approved for human therapeutic use. Consult a licensed clinician before any use.