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Cognitive comparison

Dihexa vs Selank

An educational, source-based comparison of Dihexa and Selank — how each peptide works, what it's researched for, and what to know before going deeper.

Nootropic · Synaptogenesis
Dihexa

Angiotensin IV analog researched for synaptogenesis.

Mechanism

A hexapeptide derived from angiotensin IV that crosses the blood-brain barrier and potentiates hepatocyte growth factor (HGF) / c-Met signaling, associated with new synapse formation in preclinical models.

Research areas
  • Synaptogenesis and dendritic spine density
  • Alzheimer's and cognitive aging models
  • Memory consolidation in rodents
Considerations
  • No human clinical trial data; theoretical proliferation concerns via HGF/c-Met.
  • Not FDA-approved.
Full Dihexa profile →
Anxiolytic · Nootropic
Selank

Anxiolytic-style peptide researched for stress modulation.

Mechanism

A synthetic analog of the immunomodulatory peptide tuftsin. Research suggests it modulates GABAergic and serotonergic systems and influences expression of brain-derived neurotrophic factor without the sedation or dependence profile of benzodiazepines.

Research areas
  • Generalized anxiety models
  • BDNF expression
  • Immune modulation
  • Memory and learning in rodent models
Considerations
  • Not FDA-approved.
  • Most studies are Russian clinical literature.
Full Selank profile →

Dihexa vs Selank — Key differences

  • Class: Dihexa is classified as Nootropic · Synaptogenesis, while Selank is Anxiolytic · Nootropic.
  • Primary research focus: Dihexasynaptogenesis and dendritic spine density; Selankgeneralized anxiety models.
  • Tag: Cognition vs Calm · Cognition.

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