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Immune comparison

ARA-290 vs VIP (Vasoactive Intestinal Peptide)

An educational, source-based comparison of ARA-290 and VIP (Vasoactive Intestinal Peptide) — how each peptide works, what it's researched for, and what to know before going deeper.

Neuropathic · Immune Modulation
ARA-290

Erythropoietin-derived peptide researched for neuropathy and tissue repair.

Mechanism

A synthetic 11-amino-acid peptide derived from the erythropoietin molecule. Research indicates it retains the tissue-protective (non-erythropoietic) effects of EPO via the β-common receptor, without stimulating red blood cell production.

Research areas
  • Small-fiber neuropathy and sarcoidosis
  • Diabetic neuropathy
  • Ischemia-reperfusion injury
  • Autoimmune modulation
Considerations
  • Investigational; not FDA-approved.
  • Does not raise hematocrit like full EPO molecule.
Full ARA-290 profile →
Immune · Respiratory
VIP (Vasoactive Intestinal Peptide)

Neuropeptide researched for immune modulation and lung protection.

Mechanism

A 28-amino-acid neuropeptide with broad immunomodulatory, anti-inflammatory, and bronchodilatory effects. Acts via VPAC1 and VPAC2 receptors to regulate T-cell function, macrophage polarization, and airway smooth muscle tone.

Research areas
  • Acute respiratory distress syndrome (ARDS)
  • Chronic inflammatory conditions
  • Autoimmune modulation
  • Bronchial asthma and COPD
Considerations
  • Short half-life limits therapeutic utility; analogs in development.
  • Not FDA-approved in native form.
Full VIP (Vasoactive Intestinal Peptide) profile →

ARA-290 vs VIP (Vasoactive Intestinal Peptide) — Key differences

  • Class: ARA-290 is classified as Neuropathic · Immune Modulation, while VIP (Vasoactive Intestinal Peptide) is Immune · Respiratory.
  • Primary research focus: ARA-290small-fiber neuropathy and sarcoidosis; VIP (Vasoactive Intestinal Peptide)acute respiratory distress syndrome (ards).
  • Tag: Neuropathic pain · Immune vs Immune · Respiratory.

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